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Yeast Fitness
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YLL051C / FRE6


Section 1: Phenotypes.
Gene-drug relationships for FRE6
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the FRE6 deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see The Chemical Genomic Portrait of Yeast.

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Heterozygous knockout:

Top 10 sensitivity-inducing conditions for FRE6 Heterozygous deletion:

Condition1 Conc Unit FitnessDefect (z-score) P-value
miconazole 0.2 uM 19.7652 0.00000000000057399
miconazole 25 nM 12.4546 0.0000000000016245
5-fluorocytosine 15.6 uM 6.42981 0.000000030006
alverine citrate 500 uM 5.90436 0.00003602
clozapine 125 uM 5.30372 0.0000014958
cantharidin 200 uM 4.80433 0.000017533
methotrexate 500 uM 4.36669 0.000061873
caspofungin 10 nM 4.12301 0.000075472
caspofungin 10 nM 4.06723 0.000090098
methotrexate 500 uM 3.94726 0.00020304

More... (click to see all Heterozygous data)
 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for FRE6 Homozygous deletion:

Condition1 Conc Unit FitnessDefect (z-score) P-value
licl 100 mM 5.44353 0.000017959
PABA drop-out

2.77854 0.054398
mechlorethamine 62.5 uM 2.15911 0.059838
sorbitol 1500000 uM 2.14196 0.023486
mechlorethamine 62.5 uM 1.79671 0.10711
sorbitol 1500000 uM 1.66391 0.054069
synthetic complete for BY4743

1.54748 0.076393
synthetic complete for BY4743

1.54583 0.098521
synthetic complete for BY4743

1.43399 0.097349
wiskostatin 29 uM 1.3969 0.085747

More... (click to see all Homozygous data)



Section 2: Co-fitness interactions.
Gene-gene relationships for FRE6
(Hillenmeyer et al., Genome Biol. 2010)

This study extends the preliminary analysis of clustering genes according to co-fitness across experiments (Hillenmeyer et al., Science 2008). Here, instead of clustering genes, we analyzed the co-fitness between all pairs of genes, testing several types of correlation.


Heterozygous co-fitness interactions

Top 10 interactors with FRE6 by heterozygous co-sensitivity:

Query Interactor CoFitHet CoFitHom
FRE6 CWP1 0.60342 -0.07718
FRE6 PAU7 0.55003 0.15612
FRE6 YHR097C 0.54983 0.08375
FRE6 AHT1 0.54957 0.35955
FRE6 YAR023C 0.54756 0.26882
FRE6 PRM9 0.54616 0.56711
FRE6 LPE10 0.53941 0.22967
FRE6 YLR001C 0.53833 0.4828
FRE6 SNC1 0.53032 0.3832
FRE6 YPR077C 0.52728 0.0935

More... (click to see all interactions)

Complete data download in manuscript supplement

 Enriched GO terms of interactors

Process:
  • None
Function:Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with FRE6 by homozygous co-sensitivity:

Query Interactor CoFitHet CoFitHom
FRE6 FLO1 0.03712 0.64025
FRE6 LYS21 0.13691 0.6309
FRE6 YLL054C 0.21143 0.6106
FRE6 ALB1 0.28693 0.57713
FRE6 HCH1 0.19307 0.57395
FRE6 ECM27 0.15101 0.57325
FRE6 YPR174C 0.08293 0.57172
FRE6 PRM9 0.54616 0.56711
FRE6 SPS1 0.09653 0.56331
FRE6 SNZ2 0.34682 0.55083

More... (click to see all interactions)

Complete data download in manuscript supplement

 Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None



External information about FRE6

Other databases:

Visit YLL051C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:

Download a plain text version of this page.






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