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Yeast Fitness
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YLR013W / GAT3



Section 1: Phenotypes.
Gene-drug relationships for GAT3
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the GAT3 deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for GAT3 Heterozygous deletion:

Condition1 Conc Unit FitnessDefect (z-score) P-value
dyclonine 500 uM 4.37595 0.00045135
itraconazole 17.7 uM 3.89898 0.00015285
itraconazole 17.7 uM 3.83644 0.00018559
dna protein kinase inhibitor

3.69528 0.00040874
econazole nitrate 0.24 uM 3.23196 0.0011245
atorvastatin 125 uM 3.20033 0.0012306
tryptanthrin 250 uM 3.18763 0.0015992
telomerase inhibitor ix (Biomol) 500 uM 3.17839 0.0016383
caspofungin 10 nM 3.13976 0.0014605
resveratrol 2000 uM 3.10242 0.0019961

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for GAT3 Homozygous deletion:

Condition1 Conc Unit FitnessDefect (z-score) P-value
rapamycin 9 nM 12.2872 0.0032793
licl 100 mM 8.94442 0.000000024146
synthetic complete for BY4743

8.58539 0.0016609
nocodazole 10 ug/ml 6.1643 0.000004032
fk506 0.05 ug/ml 5.36698 0.0000028659
latrunculin 0.78 uM 5.30378 0.01688
synthetic complete for BY4743

5.29946 0.016906
latrunculin 3 uM 5.1141 0.000036286
nocodazole 10 ug/ml 5.10664 0.000036874
myriocin 0.2 ug/ml 5.00001 0.00004642

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for GAT3
(Hillenmeyer et al., Genome Biol. 2010)

This study extends the preliminary analysis of clustering genes according to co-fitness across experiments (Hillenmeyer et al., Science 2008). Here, instead of clustering genes, we analyzed the co-fitness between all pairs of genes, testing several types of correlation.


Heterozygous co-fitness interactions

Top 10 interactors with GAT3 by heterozygous co-sensitivity:

Query Interactor CoFitHet CoFitHom
GAT3 YHR033W 0.50028 0.24755
GAT3 LOT6 0.43362 0.58606
GAT3 NTG2 0.40874 0.25007
GAT3 YDL183C 0.40651 -0.08535
GAT3 SIR1 0.39299 -0.01904
GAT3 VMR1 0.39124 0.00299
GAT3 ARN2 0.38753 0.10671
GAT3 YOR022C 0.37995 -0.04151
GAT3 CAR1 0.37867 0.22139
GAT3 YJR124C 0.37701 0.16139

More... (click to see all interactions)

Complete data download in manuscript supplement

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with GAT3 by homozygous co-sensitivity:

Query Interactor CoFitHet CoFitHom
GAT3 DBP1 0.26686 0.76329
GAT3 FMS1 0.08412 0.6951
GAT3 FSH1 0.18858 0.69205
GAT3 YME2 0.207 0.68943
GAT3 ADH2 0.20824 0.67242
GAT3 AHT1 0.16899 0.66892
GAT3 YMR278W 0.30777 0.66827
GAT3 RDS1 0.05521 0.66461
GAT3 YJR020W 0.25821 0.65992
GAT3 YPR014C 0.0067 0.6567

More... (click to see all interactions)

Complete data download in manuscript supplement

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about GAT3

Other databases:

Visit YLR013W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:

Download a plain text version of this page.






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