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Yeast Fitness
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YKL128C / PMU1



Section 1: Phenotypes.
Gene-drug relationships for PMU1
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the PMU1 deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for PMU1 Heterozygous deletion:

Condition1 Conc Unit FitnessDefect (z-score) P-value
bufexamac 1000 uM 7.79468 0.00000000025996
bufexamac 1000 uM 7.54279 0.00000000061925
atorvastatin 125 uM 4.59414 0.000016347
lovastatin 154.5 uM 4.10464 0.000080014
caspofungin 50 nM 3.95155 0.0001297
nimustine 1000 uM 3.76307 0.00023267
mechlorethamine 62.5 uM 3.63544 0.00034318
emodin 1000 uM 3.58444 0.00040017
fk506 100 uM 3.55274 0.00060359
clozapine 500 uM 3.48656 0.00053588

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for PMU1 Homozygous deletion:

Condition1 Conc Unit FitnessDefect (z-score) P-value
methoxsalen 500 uM 4.66802 0.000040369
synthetic complete for BY4743

3.40954 0.021082
curcumin 150 uM 2.33177 0.015765
25 degrees C

2.31889 0.021427
synthetic complete for BY4743

2.21799 0.078408
synthetic complete for BY4743

2.17256 0.047768
5-fluorouracil 19.2 uM 2.00086 0.036641
synthetic complete for BY4743

1.94954 0.054367
ph4 8
1.78623 0.041491
synthetic complete for BY4743

1.76244 0.088101

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for PMU1
(Hillenmeyer et al., Genome Biol. 2010)

This study extends the preliminary analysis of clustering genes according to co-fitness across experiments (Hillenmeyer et al., Science 2008). Here, instead of clustering genes, we analyzed the co-fitness between all pairs of genes, testing several types of correlation.


Heterozygous co-fitness interactions

Top 10 interactors with PMU1 by heterozygous co-sensitivity:

Query Interactor CoFitHet CoFitHom
PMU1 YFR045W 0.53477 0.41623
PMU1 BNI4 0.5319 0.28318
PMU1 ARR2 0.51151 0.24039
PMU1 SCS3 0.50258 0.02648
PMU1 ORT1 0.47958 -0.02353
PMU1 YOR283W 0.47607 0.46112
PMU1 CNB1 0.4723 -0.06245
PMU1 ADH7 0.46732 0.35083
PMU1 SPE1 0.45322 0.42534
PMU1 CUP2 0.45148 0.21384

More... (click to see all interactions)

Complete data download in manuscript supplement

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with PMU1 by homozygous co-sensitivity:

Query Interactor CoFitHet CoFitHom
PMU1 YGL235W -0.06707 0.76171
PMU1 CPD1 0.27363 0.75202
PMU1 MDM1 0.01687 0.72827
PMU1 YKL162C 0.23365 0.71619
PMU1 PCL1 -0.09221 0.70403
PMU1 HSP104 -0.09661 0.69822
PMU1 ABP140 0.1367 0.69408
PMU1 IME1 0.05042 0.69018
PMU1 YKL161C 0.07438 0.68713
PMU1 YGL082W 0.10708 0.6849

More... (click to see all interactions)

Complete data download in manuscript supplement

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about PMU1

Other databases:

Visit YKL128C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:

Download a plain text version of this page.






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