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Yeast Fitness


Enter orf / gene / drug:

(e.g. pex22 or lovastatin)  

YLR212C / TUB4

Section 1: Phenotypes.
Gene-drug relationships for TUB4
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the TUB4 deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for TUB4 Heterozygous deletion:

Condition1 Conc Unit FitnessDefect (z-score) P-value
licl 150 mM 6.31765 0.00000021706
telomerase inhibitor ix (Biomol) 500 uM 5.75076 0.0000011181
fluconazole 65.3 uM 5.4338 0.00000095714
amphotericin b 0.31 uM 5.0793 0.0000032152
amphotericin b 0.62 uM 4.61683 0.000015165
fluconazole 130.6 uM 4.12336 0.000075386
fenbendazole 500 uM 3.61873 0.00036094
p-aminobenzoic acid 500 uM 3.33533 0.0010831
fenpropimorph 1.2 uM 3.18135 0.0012987
mitomycin c 1000 uM 3.1676 0.0013502

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for TUB4
(Hillenmeyer et al., Genome Biol. 2010)

This study extends the preliminary analysis of clustering genes according to co-fitness across experiments (Hillenmeyer et al., Science 2008). Here, instead of clustering genes, we analyzed the co-fitness between all pairs of genes, testing several types of correlation.

Heterozygous co-fitness interactions

Top 10 interactors with TUB4 by heterozygous co-sensitivity:

Query Interactor CoFitHet CoFitHom
TUB4 FHL1 0.57767 0
TUB4 ATP11 0.55443 0
TUB4 CPR7 0.52886 0
TUB4 RIB7 0.52365 0
TUB4 TMA23 0.52216 0
TUB4 SMT3 0.51412 0
TUB4 SRP21 0.50513 0
TUB4 SWF1 0.50499 0
TUB4 BET2 0.50037 0
TUB4 PRP24 0.49952 0

More... (click to see all interactions)

Complete data download in manuscript supplement

Enriched GO terms of interactors

  • None
  • None
  • None
Homozygous co-fitness interactions

[No homozygous results.]

External information about TUB4

Other databases:

Visit YLR212C in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:

Download a plain text version of this page.

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