Retrieving results for YCL007C, please wait...

Yeast Fitness
Database

Search

Enter orf / gene / drug:

(e.g. pex22 or lovastatin)  

YCL007C / YCL007C



Section 1: Phenotypes.
Gene-drug relationships for YCL007C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YCL007C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for YCL007C Heterozygous deletion:

Condition1 Conc Unit FitnessDefect (z-score) P-value
doxorubicin 62.5 uM 13.1324 0.0000000000016245
nocodazole 2 ug/ml 12.5559 0.0000000000016245
calyculin a 2.5 uM 10.9511 0.0000000000011727
daunorubicin 125 uM 7.04833 0.0000000034538
ketoconazole 11.8 uM 6.69308 0.0000025823
clotrimazole 1 uM 6.68488 0.000000012297
caspofungin 10 nM 6.60925 0.00000001602
caspofungin 10 nM 6.27834 0.000000050952
caspofungin 10 nM 6.26798 0.00000005283
dmso 4% 4 uM 6.06873 0.00000010591

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for YCL007C Homozygous deletion:

Condition1 Conc Unit FitnessDefect (z-score) P-value
synthetic complete for BY4743

7.70578 0.0022713
synthetic complete for BY4743

7.51337 0.000067885
synthetic complete for BY4743

7.32153 0.00007989
potassium disulfite 2500 uM 5.54526 0.000014489
synthetic complete for BY4743

5.01841 0.0020203
latrunculin 0.78 uM 4.59169 0.00011317
synthetic complete for BY4743

4.49855 0.0032041
curcumin 150 uM 4.32221 0.0002052
synthetic complete for BY4743

4.22225 0.0019628
ph4 7.5
4.20016 0.00026901

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YCL007C
(Hillenmeyer et al., Genome Biol. 2010)

This study extends the preliminary analysis of clustering genes according to co-fitness across experiments (Hillenmeyer et al., Science 2008). Here, instead of clustering genes, we analyzed the co-fitness between all pairs of genes, testing several types of correlation.


Heterozygous co-fitness interactions

Top 10 interactors with YCL007C by heterozygous co-sensitivity:

Query Interactor CoFitHet CoFitHom
YCL007C VMA5 0.49967 0
YCL007C VMA7 0.46604 0
YCL007C CUP5 0.45402 0
YCL007C RET2 0.41556 0
YCL007C SEC26 0.4046 0
YCL007C SPC42 0.39915 0
YCL007C PMR1 0.39768 0
YCL007C MSS4 0.39481 0
YCL007C YKL036C 0.39358 0
YCL007C RMD9 0.38234 0

More... (click to see all interactions)

Complete data download in manuscript supplement

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

[No homozygous results.]




External information about YCL007C

Other databases:

Visit YCL007C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
    Process:
    • None
    Function:
    • None
    Component:
    • None


Download a plain text version of this page.






Pageloads since April 18, 2008

View website stats