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YDL034W / YDL034W



Section 1: Phenotypes.
Gene-drug relationships for YDL034W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YDL034W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for YDL034W Heterozygous deletion:

Condition1 Conc Unit FitnessDefect (z-score) P-value
methotrexate 500 uM 16.631 < 1e-12
methotrexate 500 uM 16.0499 < 1e-12
paraquat 2000 uM 15.5587 < 1e-12
paraquat 2000 uM 15.4288 < 1e-12
paraquat 2000 uM 14.8474 < 1e-12
myriocin 0.15 ug/ml 11.812 0.00000000000016603
methotrexate 250 uM 11.2674 0.00000000000056583
paraquat 5000 uM 8.74825 0.00000000026859
methotrexate 250 uM 8.69236 0.00000000031084
methotrexate 500 uM 8.26349 0.00000000096649

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for YDL034W Homozygous deletion:

Condition1 Conc Unit FitnessDefect (z-score) P-value
ph4 7.5
4.85194 0.000064022
psoralen 0.5 uM 3.47379 0.0013549
carboplatin 700 uM 2.92381 0.0045333
benomyl 10 ug/ml 2.70739 0.0072117
Tyrphostin 6.2 uM 2.63349 0.0063129
nacl 1000 uM 2.59405 0.013382
25 degrees C

2.54659 0.014517
ph8

2.4832 0.0098975
23 degrees C

2.42139 0.017988
ph4 7.5
2.38352 0.014185

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YDL034W
(Hillenmeyer et al., Genome Biol. 2010)

This study extends the preliminary analysis of clustering genes according to co-fitness across experiments (Hillenmeyer et al., Science 2008). Here, instead of clustering genes, we analyzed the co-fitness between all pairs of genes, testing several types of correlation.


Heterozygous co-fitness interactions

Top 10 interactors with YDL034W by heterozygous co-sensitivity:

Query Interactor CoFitHet CoFitHom
YDL034W PRP11 0.65302 0
YDL034W FAP1 0.4108 -0.17946
YDL034W YOR072W 0.40462 -0.08713
YDL034W CTS1 0.36955 0.21976
YDL034W PSD1 0.3615 0
YDL034W SED1 0.33467 0.03481
YDL034W PRM8 0.32275 0.05544
YDL034W ARL1 0.31931 -0.00175
YDL034W YBT1 0.31069 -0.01626
YDL034W YPL056C 0.31002 -0.10943

More... (click to see all interactions)

Complete data download in manuscript supplement

Enriched GO terms of interactors

Process:Function:
  • None
Component:
 
Homozygous co-fitness interactions

Top 10 interactors with YDL034W by homozygous co-sensitivity:

Query Interactor CoFitHet CoFitHom
YDL034W MSH3 0.05953 0.66795
YDL034W OSW1 0.04274 0.6314
YDL034W ISF1 0.13676 0.6151
YDL034W YMR130W 0.03135 0.61332
YDL034W PRM7 0.0328 0.57855
YDL034W GSP2 0.0029 0.57523
YDL034W YKR104W 0.12501 0.56887
YDL034W YGL109W 0.09905 0.56828
YDL034W YKL105C 0.0673 0.56389
YDL034W RTN2 0.11111 0.5613

More... (click to see all interactions)

Complete data download in manuscript supplement

Enriched GO terms of interactors

Process:
  • None
Function:Component:
  • None




External information about YDL034W

Other databases:

Visit YDL034W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
    Process:
    • None
    Function:
    • None
    Component:
    • None


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