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Yeast Fitness
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YDL071C / IRC1



Section 1: Phenotypes.
Gene-drug relationships for YDL071C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YDL071C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for IRC1 Heterozygous deletion:

Condition1 Conc Unit FitnessDefect (z-score) P-value
nocodazole 2 ug/ml 13.1635 0.0000000000016244
thiabendazole 250 uM 9.82066 0.0000000000019107
caspofungin 10 nM 8.1299 0.000000000083179
cantharidin 250 uM 7.98461 0.0076628
cloxyquin 15.6 uM 7.96525 0.00000000014515
wiskostatin 29 uM 6.94814 0.000000035994
cantharidin 250 uM 6.78219 0.010528
bufexamac 1000 uM 6.4284 0.000000030154
itraconazole 8.8 uM 5.99719 0.00000013591
drofenine hydrochloride 750 uM 5.39891 0.0000010791

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for IRC1 Homozygous deletion:

Condition1 Conc Unit FitnessDefect (z-score) P-value
wiskostatin 29 uM 16.4295 < 1e-12
23 degrees C

10.0764 0.00000074121
rapamycin 6 nM 7.45942 0.0000000058993
thiabendazole 250 uM 7.07959 0.000000080796
sorbitol 1500000 uM 5.60486 0.0000034317
mechlorethamine 62.5 uM 5.14478 0.000011471
mms 0.002 % 5.11391 0.0000061122
rapamycin 4.88 nM 4.94964 0.0000099809
mms 0.002 % 4.89656 0.019634
licl 150 mM 4.81097 0.000015081

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YDL071C
(Hillenmeyer et al., Genome Biol. 2010)

This study extends the preliminary analysis of clustering genes according to co-fitness across experiments (Hillenmeyer et al., Science 2008). Here, instead of clustering genes, we analyzed the co-fitness between all pairs of genes, testing several types of correlation.


Heterozygous co-fitness interactions

Top 10 interactors with IRC1 by heterozygous co-sensitivity:

Query Interactor CoFitHet CoFitHom
IRC1 YGR146C 0.50838 -0.01821
IRC1 SWR1 0.45132 0.24633
IRC1 WSC2 0.39962 0.06715
IRC1 EXG1 0.36958 -0.2769
IRC1 SPH1 0.36722 -0.04155
IRC1 SEC72 0.36587 -0.21755
IRC1 PPZ2 0.36281 -0.22378
IRC1 YLR287C 0.35539 0.05715
IRC1 HFD1 0.35264 0.38034
IRC1 YLR279W 0.35215 0.19073

More... (click to see all interactions)

Complete data download in manuscript supplement

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with IRC1 by homozygous co-sensitivity:

Query Interactor CoFitHet CoFitHom
IRC1 BDF2 0.1823 0.55129
IRC1 YPR092W 0.09773 0.54801
IRC1 YOR053W 0.00668 0.51235
IRC1 MVP1 0.04545 0.46698
IRC1 SVF1 0.24809 0.46554
IRC1 URA5 0.21949 0.46206
IRC1 YDL057W 0.07926 0.46162
IRC1 YMR31 0.14524 0.44831
IRC1 YLR137W 0.20087 0.44775
IRC1 NDE1 0.15129 0.4427

More... (click to see all interactions)

Complete data download in manuscript supplement

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YDL071C

Other databases:

Visit YDL071C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
    Process:
    • None
    Function:
    • None
    Component:
    • None


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