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YDR015C / YDR015C



Section 1: Phenotypes.
Gene-drug relationships for YDR015C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YDR015C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for YDR015C Heterozygous deletion:

Condition1 Conc Unit FitnessDefect (z-score) P-value
latrunculin 3.91 uM 11.4443 0.00000000000037831
methotrexate 500 uM 11.4241 0.00000000000039613
lapachol 1000 uM 6.32395 0.000000043445
trichlormethine 1000 uM 4.59825 0.000016126
mechlorethamine 500 uM 4.09389 0.000082792
k2cr2o7 6.25 uM 4.0844 0.00013806
bufexamac 1000 uM 3.63096 0.00034786
bufexamac 1000 uM 3.4814 0.00054413
mechlorethamine 500 uM 3.37104 0.00075266
tryptanthrin 250 uM 3.1601 0.0017184

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for YDR015C Homozygous deletion:

Condition1 Conc Unit FitnessDefect (z-score) P-value
nocodazole 10 ug/ml 8.16047 0.000000092241
methotrexate 250 uM 4.98876 0.000017308
allyl disulfide 0.06 % 4.85589 0.000013195
nitric oxide 800 uM 4.71766 0.000035409
mms 0.002 % 4.49668 0.023033
mechlorethamine 62.5 uM 3.90653 0.029859
ph4 8
3.79968 0.00028635
synthetic complete for BY4743

3.78014 0.0018006
ph4 7.5
3.74952 0.00073375
angelicin 62.5 uM 3.32007 0.0019044

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YDR015C
(Hillenmeyer et al., Genome Biol. 2010)

This study extends the preliminary analysis of clustering genes according to co-fitness across experiments (Hillenmeyer et al., Science 2008). Here, instead of clustering genes, we analyzed the co-fitness between all pairs of genes, testing several types of correlation.


Heterozygous co-fitness interactions

Top 10 interactors with YDR015C by heterozygous co-sensitivity:

Query Interactor CoFitHet CoFitHom
YDR015C MCH4 0.45183 -0.21997
YDR015C MNN5 0.39015 -0.01901
YDR015C YDR026C 0.37845 -0.05282
YDR015C MDH3 0.3668 0.14982
YDR015C TNA1 0.36668 -0.01125
YDR015C BSC6 0.36492 0.11368
YDR015C MNN1 0.36047 0.27628
YDR015C ERV15 0.35954 -0.21243
YDR015C YJL185C 0.35923 0.06982
YDR015C YPL206C 0.35582 0.04062

More... (click to see all interactions)

Complete data download in manuscript supplement

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with YDR015C by homozygous co-sensitivity:

Query Interactor CoFitHet CoFitHom
YDR015C PCL1 0.2231 0.55877
YDR015C PTP2 0.14491 0.52678
YDR015C YKL061W 0.06536 0.52472
YDR015C TWF1 0.14208 0.52018
YDR015C YMR171C 0.16351 0.50392
YDR015C YOR325W 0.04862 0.49528
YDR015C ARF3 0.19354 0.49504
YDR015C EMP46 0.01404 0.49452
YDR015C YKL162C 0.13571 0.49134
YDR015C OAC1 0.10634 0.48829

More... (click to see all interactions)

Complete data download in manuscript supplement

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YDR015C

Other databases:

Visit YDR015C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
    Process:
    • None
    Function:
    • None
    Component:
    • None


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