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YEL059W / YEL059W


Section 1: Phenotypes.
Gene-drug relationships for YEL059W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YEL059W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for YEL059W Heterozygous deletion:

Condition1 Conc Unit FitnessDefect (z-score) P-value
bufexamac 1000 uM 9.05617 0.0000000000051751
drofenine hydrochloride 750 uM 9.01596 0.0000000000056852
dyclonine 500 uM 7.59488 0.0000031873
metergoline 250 uM 7.39863 0.0000000010205
clotrimazole 1 uM 6.92652 0.0000000052841
clozapine 500 uM 6.87989 0.0000000062189
propiomazine maleate 500 uM 6.55047 0.000000019676
methotrexate 125 uM 6.47962 0.00000013638
hydroxyurea 100000 uM 6.38014 0.000000035697
caspofungin 10 nM 6.36144 0.000000038109

More... (click to see all Heterozygous data)
 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for YEL059W Homozygous deletion:

Condition1 Conc Unit FitnessDefect (z-score) P-value
nocodazole 10 ug/ml 13.0076 0.000000000068184
licl 100 mM 10.3029 0.0000000028157
mncl2 2 mM 7.28203 0.0000000098414
ph8

7.23398 0.000014055
latrunculin 0.78 uM 6.74982 0.003321
ph4 7.5
5.66251 0.00001133
tryptanthrin 250 uM 5.51646 0.0000018313
ph8

5.3728 0.00015664
5-fluorouracil 38.5 uM 4.63707 0.000043807
cuso4 12000 uM 4.25411 0.00012018

More... (click to see all Homozygous data)



Section 2: Co-fitness interactions.
Gene-gene relationships for YEL059W
(Hillenmeyer et al., Genome Biol. 2010)

This study extends the preliminary analysis of clustering genes according to co-fitness across experiments (Hillenmeyer et al., Science 2008). Here, instead of clustering genes, we analyzed the co-fitness between all pairs of genes, testing several types of correlation.


Heterozygous co-fitness interactions

Top 10 interactors with YEL059W by heterozygous co-sensitivity:

Query Interactor CoFitHet CoFitHom
YEL059W MRPL33 0.48162 -0.11383
YEL059W KRE29 0.44721 0
YEL059W YMR160W 0.44618 0
YEL059W PIK1 0.433 0
YEL059W DDR48 0.43017 0
YEL059W UTP7 0.42399 0
YEL059W ARB1 0.42172 0
YEL059W SPF1 0.42157 0.06348
YEL059W GUA1 0.41963 0
YEL059W SWP1 0.41933 0

More... (click to see all interactions)

Complete data download in manuscript supplement

 Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with YEL059W by homozygous co-sensitivity:

Query Interactor CoFitHet CoFitHom
YEL059W CNA1 -0.13385 0.40254
YEL059W RHO2 -0.1586 0.38009
YEL059W YER097W -0.038 0.37581
YEL059W APL1 -0.17988 0.37452
YEL059W YER113C -0.24808 0.368
YEL059W REC107 -0.09792 0.36408
YEL059W YMR317W -0.05558 0.36181
YEL059W YMR084W -0.02328 0.35964
YEL059W YER140W -0.16636 0.35494
YEL059W HXT4 -0.2006 0.3499

More... (click to see all interactions)

Complete data download in manuscript supplement

 Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None



External information about YEL059W

Other databases:

Visit YEL059W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
    Process:
    • None
    Function:
    • None
    Component:
    • None


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