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YER046W-A / YER046W-A


Section 1: Phenotypes.
Gene-drug relationships for YER046W-A
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YER046W-A deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for YER046W-A Heterozygous deletion:

Condition1 Conc Unit FitnessDefect (z-score) P-value
miconazole 0.2 uM 8.38082 0.00000015089
tryptanthrin 250 uM 6.51048 0.00000012485
nacl 700 mM 5.54308 0.0000020451
itraconazole 17.7 uM 5.40166 0.0000010689
licl 150 mM 5.23861 0.0000049625
fluconazole 130.6 uM 4.95212 0.0000049444
miconazole 25 nM 4.91833 0.0000055409
methotrexate 500 uM 4.79118 0.000018213
itraconazole 17.7 uM 4.44711 0.000026506
5-fluorouridine 95 uM 4.43018 0.000028014

More... (click to see all Heterozygous data)
 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for YER046W-A Homozygous deletion:

Condition1 Conc Unit FitnessDefect (z-score) P-value
nocodazole 10 ug/ml 7.7008 0.00000020996
licl 100 mM 7.37893 0.00000037977
latrunculin 3 uM 6.7304 0.0000013078
ph4 8
5.56867 0.000001566
zncl2 1875 uM 5.41415 0.0000024883
synthetic complete for BY4743

5.07302 0.007396
ph4 8
4.81565 0.000014872
mncl2 2 mM 4.66128 0.000023508
myriocin 0.2 ug/ml 4.58476 0.00011491
fk506 0.05 ug/ml 4.11398 0.00011664

More... (click to see all Homozygous data)



Section 2: Co-fitness interactions.
Gene-gene relationships for YER046W-A
(Hillenmeyer et al., Genome Biol. 2010)

This study extends the preliminary analysis of clustering genes according to co-fitness across experiments (Hillenmeyer et al., Science 2008). Here, instead of clustering genes, we analyzed the co-fitness between all pairs of genes, testing several types of correlation.


Heterozygous co-fitness interactions

Top 10 interactors with YER046W-A by heterozygous co-sensitivity:

Query Interactor CoFitHet CoFitHom
YER046W-A HSP10 0.54725 0
YER046W-A AEP2 0.51814 -0.09827
YER046W-A ERG28 0.51508 0
YER046W-A ISC1 0.51042 0.11832
YER046W-A BUD16 0.4994 0
YER046W-A KRE29 0.49747 0
YER046W-A YMR293C 0.49547 -0.28857
YER046W-A PAU13 0.49159 0.34293
YER046W-A PET117 0.49037 -0.12745
YER046W-A YER087W 0.47299 -0.31154

More... (click to see all interactions)

Complete data download in manuscript supplement

 Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with YER046W-A by homozygous co-sensitivity:

Query Interactor CoFitHet CoFitHom
YER046W-A GSM1 -0.15085 0.56102
YER046W-A MRL1 0.04778 0.54386
YER046W-A YOR059C 0.20031 0.53138
YER046W-A PYC2 -0.16077 0.52337
YER046W-A ALP1 0.14662 0.51457
YER046W-A YDL177C -0.10775 0.51367
YER046W-A CRH1 0.09006 0.51357
YER046W-A YLR456W -0.00926 0.50248
YER046W-A TDH2 0.13956 0.49931
YER046W-A YJL068C -0.14182 0.48755

More... (click to see all interactions)

Complete data download in manuscript supplement

 Enriched GO terms of interactors

Process:Function:Component:
  • None



External information about YER046W-A

Other databases:

Visit YER046W-A in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
    Process:
    • None
    Function:
    • None
    Component:
    • None


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