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YER067C-A / YER067C-A
Section 1: Phenotypes.
Gene-drug relationships for YER067C-A
(Hillenmeyer et al., Science 2008)
The top 10 experiments that caused a fitness defect in the YER067C-A deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.
We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast
.
.
Heterozygous knockout:
Top 10 sensitivity-inducing conditions for YER067C-A Heterozygous deletion:
Condition1
Conc
Unit
FitnessDefect (z-score)
P-value
latrunculin
6.25
uM
6.33543
0.0000049506
bithionol
75
uM
5.79479
0.00000027478
trichostatin A
3.91
uM
5.49635
0.0000023431
hydroxyurea
25000
uM
4.10932
0.000078831
itraconazole
17.7
uM
3.70544
0.0002775
miconazole
100
uM
3.70108
0.00028121
ketoconazole
11.8
uM
3.48137
0.0015412
mycophenolic acid
125
uM
3.4121
0.00066748
dihydromotuporamine C
15
uM
3.3871
0.00094345
miconazole
50
nM
3.17005
0.0040344
More
... (click to see all Heterozygous data)
Homozygous knockout:
Top 10 sensitivity-inducing conditions for YER067C-A Homozygous deletion:
Condition1
Conc
Unit
FitnessDefect (z-score)
P-value
licl
100
mM
18.0899
0.00000000000027034
licl
150
mM
9.57681
0.000000000017443
licl
150
mM
7.84096
0.0000000019847
nocodazole
10
ug/ml
5.53863
0.000014692
thiabendazole
250
uM
5.10248
0.000012824
licl
100
mM
4.80194
0.000071396
PABA drop-out
4.58497
0.022212
cantharidin
100
uM
3.48167
0.0013315
licl
100
mM
3.24629
0.0022409
latrunculin
3
uM
3.1707
0.0026462
More
... (click to see all Homozygous data)
Section 2: Co-fitness interactions.
Gene-gene relationships for YER067C-A
(Hillenmeyer et al., Genome Biol. 2010)
This study extends the preliminary analysis of clustering genes according to co-fitness across experiments (Hillenmeyer et al., Science 2008). Here, instead of clustering genes, we analyzed the co-fitness between all pairs of genes, testing several types of correlation.
Heterozygous co-fitness interactions
Top 10 interactors with YER067C-A by heterozygous co-sensitivity:
Query
Interactor
CoFitHet
CoFitHom
YER067C-A
YER084W
0.52853
-0.06571
YER067C-A
ECM34
0.47533
0.25027
YER067C-A
ARN2
0.47028
0.02231
YER067C-A
YEN1
0.46937
-0.15696
YER067C-A
RKR1
0.46379
-0.13186
YER067C-A
YKL030W
0.4573
0.49285
YER067C-A
FCY21
0.4511
-0.11043
YER067C-A
YHR022C
0.43758
-0.00811
YER067C-A
SSO2
0.43194
-0.133
YER067C-A
MXR1
0.42324
0.10042
More
... (click to see all interactions)
Complete data download in manuscript supplement
Enriched GO terms of interactors
Process:
None
Function:
None
Component:
None
Homozygous co-fitness interactions
Top 10 interactors with YER067C-A by homozygous co-sensitivity:
Query
Interactor
CoFitHet
CoFitHom
YER067C-A
YNL303W
0.19605
0.80987
YER067C-A
YOR114W
0.06826
0.77968
YER067C-A
YBR116C
0.10806
0.77431
YER067C-A
BDH1
0.18828
0.75373
YER067C-A
GLO4
0.29882
0.74081
YER067C-A
PRY3
-0.04593
0.73266
YER067C-A
SSP2
0.09689
0.72226
YER067C-A
YCL076W
-0.04637
0.68979
YER067C-A
YHR113W
0.17216
0.67863
YER067C-A
CTT1
0.03746
0.67671
More
... (click to see all interactions)
Complete data download in manuscript supplement
Enriched GO terms of interactors
Process:
None
Function:
None
Component:
None
External information about YER067C-A
Other databases:
Visit YER067C-A in [
SGD
|
TheBioGrid
|
BioPixie
]
Previously known GO terms:
Process:
None
Function:
None
Component:
None
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