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YGL041C / YGL041C


Section 1: Phenotypes.
Gene-drug relationships for YGL041C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YGL041C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see The Chemical Genomic Portrait of Yeast.

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Heterozygous knockout:

Top 10 sensitivity-inducing conditions for YGL041C Heterozygous deletion:

Condition1 Conc Unit FitnessDefect (z-score) P-value
methotrexate 125 uM 4.03156 0.00010085
lovastatin 62.5 uM 3.65238 0.00032604
latrunculin 6.25 uM 3.46661 0.00159
doxorubicin 62.5 uM 3.36024 0.00077672
propiomazine maleate 500 uM 3.07205 0.0017653
5-fluorocytosine 15.6 uM 3.01578 0.002063
caspofungin 10 nM 2.98188 0.0022644
hydroxyurea 50000 uM 2.95847 0.0024141
semustine 62.5 uM 2.87139 0.0030556
benomyl 13.8 uM 2.80473 0.018891

More... (click to see all Heterozygous data)
 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for YGL041C Homozygous deletion:

Condition1 Conc Unit FitnessDefect (z-score) P-value
minimal media

3.46559 0.00092547
ph8

3.40666 0.0010742
dmso 4%

3.07749 0.002054
5-fluorouracil 38.5 uM 3.03514 0.0027016
alizarin 66 uM 3.02325 0.0023658
sorbitol 1500000 uM 2.9978 0.0029585
mms 0.002 % 2.9936 0.0025546
5-fluorouracil 19.1 uM 2.96413 0.0032099
floxuridine 3.37 uM 2.87958 0.0039339
phosphatase inhibitor 3 uM 2.80761 0.0041035

More... (click to see all Homozygous data)



Section 2: Co-fitness interactions.
Gene-gene relationships for YGL041C
(Hillenmeyer et al., Genome Biol. 2010)

This study extends the preliminary analysis of clustering genes according to co-fitness across experiments (Hillenmeyer et al., Science 2008). Here, instead of clustering genes, we analyzed the co-fitness between all pairs of genes, testing several types of correlation.


Heterozygous co-fitness interactions

Top 10 interactors with YGL041C by heterozygous co-sensitivity:

Query Interactor CoFitHet CoFitHom
YGL041C ADK1 0.55333 0
YGL041C YKL169C 0.51493 0
YGL041C SCW11 0.50986 0.20982
YGL041C PGS1 0.49073 0
YGL041C ROK1 0.48966 0
YGL041C SNU71 0.48741 0
YGL041C RAD27 0.48269 0.14887
YGL041C MET7 0.47195 0
YGL041C SIR4 0.46813 0
YGL041C GPI10 0.46456 0

More... (click to see all interactions)

Complete data download in manuscript supplement

 Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with YGL041C by homozygous co-sensitivity:

Query Interactor CoFitHet CoFitHom
YGL041C YGL138C 0.09147 0.64789
YGL041C YGL015C -0.06674 0.59026
YGL041C YDL038C -0.07663 0.56161
YGL041C ADD37 0.02416 0.55332
YGL041C HEH2 0.13009 0.54407
YGL041C YGL140C 0.22868 0.5422
YGL041C YGL132W 0.11497 0.5417
YGL041C TES1 -0.06421 0.52966
YGL041C HOT13 -0.01224 0.52846
YGL041C SMF2 0.05335 0.52823

More... (click to see all interactions)

Complete data download in manuscript supplement

 Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None



External information about YGL041C

Other databases:

Visit YGL041C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
    Process:
    • None
    Function:
    • None
    Component:
    • None


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