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YGL042C / YGL042C



Section 1: Phenotypes.
Gene-drug relationships for YGL042C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YGL042C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for YGL042C Heterozygous deletion:

Condition1 Conc Unit FitnessDefect (z-score) P-value
23 degrees C

3.26372 0.011177
helenine 250 uM 3.21768 0.0011713
methotrexate 250 uM 3.21698 0.0011736
caspofungin 10 nM 3.18339 0.0012912
caspofungin 10 nM 3.14056 0.0014573
5-fluorouracil 125 uM 3.05084 0.0018724
doxorubicin 62.5 uM 2.63755 0.005643
paraquat 2000 uM 2.52853 0.0082919
5-fluorouridine 47.5 uM 2.47105 0.0085765
miconazole 100 uM 2.43505 0.0093696

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for YGL042C Homozygous deletion:

Condition1 Conc Unit FitnessDefect (z-score) P-value
latrunculin 0.78 uM 12.1476 0.0033543
rapamycin 4.88 nM 11.8271 0.000000000000067168
mycophenolic acid 125 uM 11.6048 0.0000000000043859
wiskostatin 29 uM 11.069 0.00000000000040656
rapamycin 6 nM 10.6716 0.0000000000010756
synthetic complete for BY4743

7.114 0.0010316
thiabendazole 250 uM 7.07498 0.000000081719
latrunculin 0.78 uM 6.44546 0.011618
latrunculin 0.78 uM 5.84669 0.0049861
fk506 200 uM 5.56678 0.0000015749

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YGL042C
(Hillenmeyer et al., Genome Biol. 2010)

This study extends the preliminary analysis of clustering genes according to co-fitness across experiments (Hillenmeyer et al., Science 2008). Here, instead of clustering genes, we analyzed the co-fitness between all pairs of genes, testing several types of correlation.


Heterozygous co-fitness interactions

Top 10 interactors with YGL042C by heterozygous co-sensitivity:

Query Interactor CoFitHet CoFitHom
YGL042C BNS1 0.49821 -0.04523
YGL042C IAH1 0.45759 -0.26509
YGL042C BUD3 0.42352 -0.05841
YGL042C YER184C 0.40735 -0.16508
YGL042C PST1 0.40544 -0.14573
YGL042C APL2 0.40215 0.3599
YGL042C ARN2 0.39447 -0.14602
YGL042C YJL181W 0.38996 0.00841
YGL042C PCI8 0.38863 0.15368
YGL042C SAK1 0.38112 0.13776

More... (click to see all interactions)

Complete data download in manuscript supplement

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with YGL042C by homozygous co-sensitivity:

Query Interactor CoFitHet CoFitHom
YGL042C DST1 0.06185 0.61013
YGL042C JJJ3 -0.0925 0.52794
YGL042C OSH3 0.01519 0.51844
YGL042C YNL190W 0.12583 0.51402
YGL042C SVL3 0.31017 0.50939
YGL042C YDR415C 0.09041 0.50614
YGL042C YBL086C 0.18386 0.49096
YGL042C YPR091C -0.11895 0.49014
YGL042C PKH3 -0.05691 0.48976
YGL042C DNF2 0.14364 0.48354

More... (click to see all interactions)

Complete data download in manuscript supplement

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YGL042C

Other databases:

Visit YGL042C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
    Process:
    • None
    Function:
    • None
    Component:
    • None


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