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YGR226C / YGR226C



Section 1: Phenotypes.
Gene-drug relationships for YGR226C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YGR226C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for YGR226C Heterozygous deletion:

Condition1 Conc Unit FitnessDefect (z-score) P-value
ketoconazole 11.8 uM 17.0401 0.0000000000055646
tunicamycin 0.15 uM 7.9844 0.00000028438
itraconazole 17.7 uM 5.85563 0.00000022243
miconazole 100 uM 5.13048 0.000002702
nimustine 1000 uM 2.98381 0.0022525
cantharidin 250 uM 2.37111 0.07058
mitomycin c 1000 uM 2.32624 0.012185
juglone 200 uM 2.29874 0.0141
emodin 1000 uM 2.28799 0.013341
trichostatin A 3.91 uM 2.09935 0.021881

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for YGR226C Homozygous deletion:

Condition1 Conc Unit FitnessDefect (z-score) P-value
23 degrees C

12.2368 0.00000012152
5-fluorouracil 38.46 uM 8.71238 0.0000027681
mms 0.002 % 4.25387 0.025533
5-fluorouracil 19.2 uM 4.21912 0.00088704
tryptanthrin 250 uM 3.50253 0.00065588
cisplatin 125 uM 3.00405 0.002914
cisplatin 125 uM 2.97668 0.0031139
cisplatin 62.5 uM 2.3402 0.013611
mitomycin c 1000 uM 2.31215 0.016405
phosphatase inhibitor 3 uM 2.05372 0.023879

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YGR226C
(Hillenmeyer et al., Genome Biol. 2010)

This study extends the preliminary analysis of clustering genes according to co-fitness across experiments (Hillenmeyer et al., Science 2008). Here, instead of clustering genes, we analyzed the co-fitness between all pairs of genes, testing several types of correlation.


Heterozygous co-fitness interactions

Top 10 interactors with YGR226C by heterozygous co-sensitivity:

Query Interactor CoFitHet CoFitHom
YGR226C MET14 0.72739 0.12681
YGR226C AMA1 0.72292 0.29446
YGR226C YGL230C 0.72214 0.43602
YGR226C STF2 0.71889 0.2136
YGR226C YGR012W 0.69683 0.11606
YGR226C PGM1 0.64805 0.00842
YGR226C DYN1 0.64462 -0.20508
YGR226C CWP1 0.63335 -0.17356
YGR226C WWM1 0.62994 0.24164
YGR226C YKL131W 0.62835 0.36601

More... (click to see all interactions)

Complete data download in manuscript supplement

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with YGR226C by homozygous co-sensitivity:

Query Interactor CoFitHet CoFitHom
YGR226C YFR035C 0.37832 0.53435
YGR226C YBL029W 0.16355 0.48999
YGR226C PTK1 0.28683 0.48992
YGR226C TOS1 -0.08444 0.47704
YGR226C YBL048W -0.00393 0.47045
YGR226C IRC5 0.14308 0.46929
YGR226C WTM1 0.33337 0.46637
YGR226C YMC2 0.33068 0.46614
YGR226C YPR195C 0.52975 0.45889
YGR226C TAH1 0.13981 0.45577

More... (click to see all interactions)

Complete data download in manuscript supplement

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YGR226C

Other databases:

Visit YGR226C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:

Download a plain text version of this page.






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