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YHR095W / YHR095W



Section 1: Phenotypes.
Gene-drug relationships for YHR095W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YHR095W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for YHR095W Heterozygous deletion:

Condition1 Conc Unit FitnessDefect (z-score) P-value
miconazole 0.2 uM 8.85811 0.000000072163
methotrexate 500 uM 5.04491 0.0000087196
caspofungin 10 nM 5.02322 0.0000038884
sanguinarine sulfate 250 uM 4.32427 0.000039536
dna protein kinase inhibitor

3.79939 0.0003066
fk506 0.1 ug/ml 3.57105 0.00057425
alverine citrate 500 uM 3.4973 0.036464
tryptanthrin 250 uM 3.48751 0.00072027
fk506 0.1 ug/ml 3.42663 0.00084861
methotrexate 250 uM 3.38922 0.00093811

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for YHR095W Homozygous deletion:

Condition1 Conc Unit FitnessDefect (z-score) P-value
synthetic complete for BY4743

9.05159 0.001424
zncl2 1875 uM 5.47651 0.0000020641
latrunculin 3 uM 4.91376 0.000055966
methotrexate 500 uM 4.41261 0.00016798
sorbitol 1500000 uM 3.49968 0.00084879
myriocin 0.2 ug/ml 3.49718 0.0012864
methotrexate 250 uM 3.38806 0.0011258
acetic acid 50 uM 2.90523 0.0032052
paraquat 5000 uM 2.7389 0.0048714
chemdiv 232 62 uM 2.68252 0.0055993

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YHR095W
(Hillenmeyer et al., Genome Biol. 2010)

This study extends the preliminary analysis of clustering genes according to co-fitness across experiments (Hillenmeyer et al., Science 2008). Here, instead of clustering genes, we analyzed the co-fitness between all pairs of genes, testing several types of correlation.


Heterozygous co-fitness interactions

Top 10 interactors with YHR095W by heterozygous co-sensitivity:

Query Interactor CoFitHet CoFitHom
YHR095W HXT1 0.40808 0.41929
YHR095W YJL038C 0.39362 0.10957
YHR095W YEL025C 0.39108 0.46347
YHR095W HXT14 0.38893 0.22066
YHR095W ECM14 0.38733 0.1909
YHR095W YPT11 0.35741 0.2024
YHR095W TOK1 0.35616 0.1859
YHR095W YNR070W 0.35407 0.44202
YHR095W HST1 0.34723 0.09675
YHR095W PPR1 0.34637 -0.03094

More... (click to see all interactions)

Complete data download in manuscript supplement

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with YHR095W by homozygous co-sensitivity:

Query Interactor CoFitHet CoFitHom
YHR095W ADK2 0.08797 0.62917
YHR095W MDV1 0.06119 0.58424
YHR095W PRY1 0.20153 0.58373
YHR095W EEB1 0.13687 0.57346
YHR095W SNC1 0.11893 0.56869
YHR095W HMF1 0.28147 0.56569
YHR095W YPL272C 0.00113 0.56565
YHR095W MDM1 0.09706 0.54867
YHR095W AIP1 0.14705 0.54726
YHR095W YJL055W 0.21501 0.54581

More... (click to see all interactions)

Complete data download in manuscript supplement

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YHR095W

Other databases:

Visit YHR095W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
    Process:
    • None
    Function:
    • None
    Component:
    • None


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