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Yeast Fitness


Enter orf / gene / drug:

(e.g. pex22 or lovastatin)  

YJL015C / YJL015C

Section 1: Phenotypes.
Gene-drug relationships for YJL015C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YJL015C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for YJL015C Heterozygous deletion:

Condition1 Conc Unit FitnessDefect (z-score) P-value
thiabendazole 250 uM 9.46171 0.000000000043118
latrunculin 3.91 uM 8.02164 0.0000000018512
miconazole 0.2 uM 7.98521 0.00000028401
thiabendazole 500 uM 7.931 0.0000000001631
sodium sulfate 625 uM 7.65154 0.0000000050743
thiabendazole 250 uM 7.49662 0.00000000072653
thiabendazole 500 uM 7.31565 0.0000000013613
alverine citrate 500 uM 7.28943 0.0000048071
ketoconazole 11.8 uM 6.90629 0.0000017665
nocodazole 2 ug/ml 5.64207 0.00000046654

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YJL015C
(Hillenmeyer et al., Genome Biol. 2010)

This study extends the preliminary analysis of clustering genes according to co-fitness across experiments (Hillenmeyer et al., Science 2008). Here, instead of clustering genes, we analyzed the co-fitness between all pairs of genes, testing several types of correlation.

Heterozygous co-fitness interactions

Top 10 interactors with YJL015C by heterozygous co-sensitivity:

Query Interactor CoFitHet CoFitHom
YJL015C GPI14 0.55628 0
YJL015C VID28 0.54697 0
YJL015C TIM44 0.54619 0
YJL015C GIM5 0.52487 0
YJL015C FYV10 0.50471 0
YJL015C FAF1 0.49153 0
YJL015C YJL009W 0.46785 0
YJL015C MMF1 0.45837 0
YJL015C URM1 0.45733 0
YJL015C YML094C-A 0.45381 0

More... (click to see all interactions)

Complete data download in manuscript supplement

Enriched GO terms of interactors

  • None
  • None
Homozygous co-fitness interactions

[No homozygous results.]

External information about YJL015C

Other databases:

Visit YJL015C in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
    • None
    • None
    • None

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