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Yeast Fitness


Enter orf / gene / drug:

(e.g. pex22 or lovastatin)  

YNL018C / YNL018C

Section 1: Phenotypes.
Gene-drug relationships for YNL018C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YNL018C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for YNL018C Heterozygous deletion:

Condition1 Conc Unit FitnessDefect (z-score) P-value
wiskostatin 29 uM 4.35684 0.000063641
fluconazole 65.3 uM 4.13543 0.000072542
ketoconazole 11.8 uM 3.85552 0.00069948
dna protein kinase inhibitor

3.79021 0.0003145
methotrexate 125 uM 3.61775 0.00050557
no drug minimal media

3.49697 0.0086702
dihydromotuporamine C 15 uM 3.30518 0.0011734
caspofungin 10 nM 3.27277 0.0010004
5-fluorocytosine 15.6 uM 3.09437 0.0016588
itraconazole 8.8 uM 2.9936 0.0021928

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YNL018C
(Hillenmeyer et al., Genome Biol. 2010)

This study extends the preliminary analysis of clustering genes according to co-fitness across experiments (Hillenmeyer et al., Science 2008). Here, instead of clustering genes, we analyzed the co-fitness between all pairs of genes, testing several types of correlation.

Heterozygous co-fitness interactions

Top 10 interactors with YNL018C by heterozygous co-sensitivity:

Query Interactor CoFitHet CoFitHom
YNL018C TRS31 0.56869 0
YNL018C BUD13 0.55113 0
YNL018C NOP8 0.54767 0
YNL018C USE1 0.54264 0
YNL018C DED1 0.54222 0
YNL018C VPS66 0.54026 0
YNL018C GAA1 0.5178 0
YNL018C YMR098C 0.51019 0
YNL018C SUA7 0.49669 0
YNL018C YPR116W 0.49568 0

More... (click to see all interactions)

Complete data download in manuscript supplement

Enriched GO terms of interactors

  • None
  • None
  • None
Homozygous co-fitness interactions

[No homozygous results.]

External information about YNL018C

Other databases:

Visit YNL018C in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:

Download a plain text version of this page.

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